Dynamic Allostery of the Catabolite Activator Protein Revealed by Interatomic Forces.
The Catabolite Activator Protein (CAP) is a showcase example for entropic allostery.For full activation and DNA binding, the homodimeric protein requires the binding of two cyclic AMP (cAMP) molecules in an anti-cooperative manner, the source of which appears to be largely of entropic nature according to previous experimental studies.We here study